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New PDF release: Opioids

By E. J. Simon, T. L. Gioannini (auth.), Professor Dr.med. Albert Herz, Dr. med. Huda Akil, Dr. med. Eric J. Simon (eds.)

ISBN-10: 3642774601

ISBN-13: 9783642774607

ISBN-10: 3642774628

ISBN-13: 9783642774621

In 1957 Otto SCHAUMANN, one of many pionieers in pharmacological learn on morphine and the 1st to arrange artificial opiates, provided a mono­ graph entitled "Morphin und morphiniihnliche Verbindungen" as quantity 12 of the guide of Experimental Pharmacology. Now, 35 years later, we're publishing within the related sequence a brand new finished quantity overlaying the current prestige of opioid examine. in view that that point the subject has multiplied vastly. The id of opioid receptors and the detection in their endogenous ligands have been landmarks which opened a brand new period in opioid examine and fertilized the full box of neurobiology. The fast enhance­ ment of this box is illustrated within the determine, which represents the variety of papers released on opioid examine on the grounds that 1970 (searches played at the MEDLINE info base). 3000 Vl

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Read e-book online Opioids PDF

In 1957 Otto SCHAUMANN, one of many pionieers in pharmacological examine on morphine and the 1st to arrange artificial opiates, offered a mono­ graph entitled "Morphin und morphiniihnliche Verbindungen" as quantity 12 of the instruction manual of Experimental Pharmacology. Now, 35 years later, we're publishing within the comparable sequence a brand new complete quantity masking the current prestige of opioid examine.

Extra resources for Opioids

Example text

J Mol Recognit 2:44-48 Gioannini TL, Yao Y-H, Hiller JM, Simon EJ, Strader CD, Taylor L, Akil H, Watson S, Weiss ER, Johnson GL (1990) Studies using antibodies generated against peptide sequences from opioid binding protein and antibodies against rhodopsin. In: Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB (eds) New leads in opioid research. l opioid binding protein has structural characteristics of a G-proootein-coupled receptor. Proc Nat! Acad Sci USA 89:52-55 Goldstein A, Nestor 11 Jr, Naidu A, Newmann SR (1988) "DAKLI": a multipurpose ligand with a high affinity and selectivity for dynorphin (kappa opioid) binding sites.

This result is remarkable in view of the fact that no biospecific purification step was used. The purification involved covalent chromatography on an SH-containing Sepharose column followed by a WGA-agarose column, neither of which is specific for opioid receptors. G. 1-0pioid Binding Protein I. Antibodies Generated Against Peptide Sequences We will briefly summarize recent studies on the Il-opioid binding protein (OBP) purified in our laboratory from bovine striatal membranes as described above.

Yet another novel type of opioid receptor was found in rabbit ileum (OKA 1980). Enkephalins and their analogs had high affinity whereas opiate alkaloids were without effect. This characteristic and the finding that the tissue is more sensitive to enkephalins than to ~-endorphin suggested that this receptor is quite different from the o-receptor. The receptor was named the iota (intestinal) opioid receptor by the authors, who suggest that it may be present in intestinal tissues of other species.

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Opioids by E. J. Simon, T. L. Gioannini (auth.), Professor Dr.med. Albert Herz, Dr. med. Huda Akil, Dr. med. Eric J. Simon (eds.)


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