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Download PDF by David W. McCandless: Epilepsy: Animal and Human Correlations

By David W. McCandless

ISBN-10: 1461401089

ISBN-13: 9781461401087

The current quantity is meant to be a synopsis of seizure issues with a target of describing key experiences in animals and people. the interpretation of pertinent findings from animal reports to human reports, and to power human experiences should be emphasised. particular cogent animal studies/results which deserve exploration in human seizure issues may be designated. the present fee of translation is expected to be from 7‐9 years, and the “success” fee of translation used to be very lately indexed as lower than one part. The good fortune price is outlined as leads to human reviews which have been envisioned upfront through animal experiences. either the time among animal and human makes an attempt plus the good fortune fee desire development.

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Additional resources for Epilepsy: Animal and Human Correlations

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0 *** 1 2 3 4 1 2 3 4 1 2 3 4 CONTROL SEIZURE RECOVERY Fig. 3 Effect of bicuculine-induced seizures and recovery on regional motor cortex phosphocreatine. Data expressed as nmoles/mg dry weight. 005. , et al. Am J. Physiol. 251: p. 0 1 2 3 4 CONTROL 1 2 3 4 SEIZURE 1 2 3 4 RECOVERY Fig. 4 Effect of bicuculline-induced seizures and recovery on regional motor cortex ATP. Layers and significance as in Fig. 3. , et al. Am J. Physiol. 251: p. 01 10 8 6 4 2 CONTROL SEIZURE SHUT DOWN Fig. 5 Hippocampal CA1 phosphocreatine during and after seizure activity.

The prompt and aggressive treatment of status epileptics with benzodiazepines, followed by phenytoin is critical in a good outcome. The epidemiology of epilepsy and learning disorders has been examined (Lhatoo and Sander 2001). 0% of the general population in the USA, and learning disabilities are present in about the same numbers (Alberman 1984). As many as ¼ epilepsy patients have learning disorders, and ½ of learning impaired patients have seizures. The authors state the usual reservations, namely that in epidemiology, prevalence in epilepsy is quite difficult to ascertain due to the high 3 Epidemiology of Epilepsy 35 variability in screening tests, standardized definitions, and classifications of epilepsy.

The decrease was greater than 50% in unparalyzed mice, and glucose was similarly decreased. After 25 s, values began to return to normal. By contrast, the paralyzed ventilated room air mice had depletions of only 37% for PCr, and 25% for ATP. Those mice ventilated with 100% oxygen had unchanged cerebral metabolites (see Fig. 1). The authors comment that their results show that if the electroshock mouse model has an adequate oxygen supply, there is a capacity to balance a three- to fourfold increase in electroshock-induced energy demand.

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Epilepsy: Animal and Human Correlations by David W. McCandless


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