Epidemiology

Electrical Diseases of the Heart: Genetics, Mechanisms, by A. A. M. Wilde, P. A. Friedman, M. J. Ackerman, W.-K. Shen, PDF

By A. A. M. Wilde, P. A. Friedman, M. J. Ackerman, W.-K. Shen, Ihor Gussak, Charles Antzelevitch

ISBN-10: 1846288533

ISBN-13: 9781846288531

ISBN-10: 1846288541

ISBN-13: 9781846288548

This e-book presents a different modern and succinct distillation of the present prestige of lately delineated electric ailments of the center, emphasizing their universal and numerous scientific good points. the most recent advancements within the box of experimental and scientific cardiac electrophysiology, genetics, pharmacology and interventional treatments of varied scientific arrhythmogenic entities are featured and mentioned by way of fresh advances in simple and scientific technology. The booklet is split into seven significant elements. every one half involves chapters (total of sixty four) facing similar issues.

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Additional info for Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention

Sample text

Theoretically, generating a cardiac action potential would require an Na+ current, a Ca2+ current, and a K+ current. This is clearly an oversimplification. Indeed, the cardiac cell expresses much more different ion currents. 1–3 Thus, the cardiac action potential results from a very complex and finely tuned interplay of an ensemble of ion channels with different relationships to voltage and time. Only sophisticated computerization can approach the complexity of the cardiac action potential (see below).

21. Makita N, Bennett PB Jr, George AL Jr. Voltagegated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene. J Biol Chem 1994;269:7571– 7578. 22. Thimmapaya R, Neelands T, Niforatos W, et al. 3 splice variants. Eur J Neurosci 2005; 22:1–9. 23. George AL Jr, Knittle TJ, Tamkun MM. Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: Evidence for a distinct gene family. Proc Natl Acad Sci USA 1992;89:4893–4897.

Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res 1999;85:e1–6. 46. Marionneau C, Couette B, Liu J, et al. Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol 2005;562:223–234. 47. Hagiwara N, Irisawa H, Kameyama M. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol 1988;395:233–253. 48. Brahmajothi MV, Morales MJ, Reimer KA, et al.

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Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention by A. A. M. Wilde, P. A. Friedman, M. J. Ackerman, W.-K. Shen, Ihor Gussak, Charles Antzelevitch


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