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DNA—Ligand Interactions: From Drugs to Proteins - download pdf or read online

By Olga Kennard (auth.), Wilhelm Guschlbauer, Wolfram Saenger (eds.)

ISBN-10: 1468453831

ISBN-13: 9781468453836

ISBN-10: 1468453858

ISBN-13: 9781468453850

This quantity comprises the texts of the 19 lectures provided on the NATO-ASI - FEBS path on "DNA - ligand interactions: from medicinal drugs to proteins." The complicated learn Institute (ASIl used to be held from August thirtieth to September eleventh. 1986 within the Abbey of Fontevraud (France). The ASI used to be attended via 112 contributors from a large clinical horizon and from twentyone assorted nations. It was once ultimately a follow-up of the ASI held in Maratea. Italy in could 1981 and which was once released within the NATO ASI lifestyles technological know-how sequence as quantity forty five. whereas a lot has been realized concerning the means the mobile equipment keeps and transmits the genetic background. in addition to how those strategies are regulated. little is understood approximately how the interactions among many of the companions concerned are happening. The interactions of substances and proteins with nucleic acids are of obvious value within the realizing of those difficulties. The astounding advances in recombinant DNA expertise and the elevated sophistication of biophysical ideas. particularly >:-ray diffraction and nuclear magnetic resonance. have created a systematic atmosphere that's hugely promising for the way forward for study in molecular biology. those advances permH the intense wish that biology at the molecular point may possibly turn into a r-eality. the various contributions on the ASI awarded the latest advances during this e>:citing field.

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1984) Nuc. Acids Res. 12, 1243-1263. , & Rich, A. (1985) Nue. , in press. R. (1983c) Cold Spring Harbor Symp. on Quant. BioI. 67,207-217. R. (1982) J. Am. Chern. Soc. 104, 5540-5541. M. (1984) Nature 90B, 327-331. A. (1979) Bull. Magn. Reson. 1, 5. , & Rich, A. (1982) Nuc. Acids Res. 10, 7879-7892. A. (1982) Nuc. Acids Res. 10, 4351-4361. , & Wells, R. (1972) Biochemistry 11, 805-815. H. (1985) J. Mol. BioI. 186,463-469. , & Sasisekharan, V. (1983) J. Biomol. Str. Dynam. 1,395-416. , & Altona, C.

R. 9,791-796. R. (1981) presented at VII International Biophysics Congress, Aug. 23-28, Abstract Book p 96. R. 9, 944-955. , & Felsenfeld, G. (1981) Proc. Natl. Acad. Sci. USA 78, 1619-1623. R. 4, 1157-1167. R. 5,3335-3346. R. (1986) Biochemistry, submitted. L. (1983) J. Am. Chem. Soc. 105, 6748. J. 9, 1011-1024. , & Tinoco, I. (1974) in The Phllsical Chemistrll 0/ Nucleic Acids, Harper & Row, New York. L. (1979) J. Phys. Chern. 89,3359-3366. L. (1980) Biochemistry 19, 1388-1392. , & Bax, A. 4, 747-765.

This follows from a consideration of the differences between the general features of a right- and a left-handed stack of bases, all with an anticonformation of the nucleotide units. From examination of Fig. 7 it is apparent when the bases are stacked in a right-handed helix, the H6 or H8 base proton can be relatively close to the H2" (and possibly the HI' and H2') protons of the 5' neighboring sugar. However, in a left-handed helix both the H2 and H2" protons of one nucleotide must be remote from the base protons of neighboring nucleotide.

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DNA—Ligand Interactions: From Drugs to Proteins by Olga Kennard (auth.), Wilhelm Guschlbauer, Wolfram Saenger (eds.)


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