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Download PDF by Brian W. J. Mahy (auth.), Mauro Bendinelli, Herman Friedman: Coxsackieviruses: A General Update

By Brian W. J. Mahy (auth.), Mauro Bendinelli, Herman Friedman (eds.)

ISBN-10: 1475702477

ISBN-13: 9781475702477

ISBN-10: 1475702493

ISBN-13: 9781475702491

It is now simply forty years due to the fact coxsackieviruses have been first remoted via Dalldorf and Sickles within the "eponymous" city of Coxsackie, ny. but the final contribution of coxsackieviruses to clinically obtrusive dis­ ease of people continues to be mostly an open challenge. Following their discov­ ery, coxsackieviruses have been lower than severe medical and laboratory scrutiny for a very long time. due to their courting to polioviruses, the less than­ status in their constitution, biochemistry, biology, and epidemiology advert­ vanced quickly as a result ambitious efforts that at last resulted in the defeat of poliomyelitis. the facility of those viruses to contaminate mice approved dissection in their pathogenicity in an experimental host and elucidation of stipulations that impression its expression. Coxsackieviruses were gradually linked to an expanding array of commonly different human ailments. even if, just some of the recommended causal correlations were substantiated with passable walk in the park. For others, conclusive proof has up to now resisted research. such a lot impor­ tant, one of the latter are persistent maladies, corresponding to dilated vehicle­ diomyopathy and juvenile diabetes, that call for attention. in recent years, there was a partial eclipse of the topic of coxsackieviruses within the scientific literature. as well as the problems encountered in pinpointing their pathogenic power, attainable purposes comprise the final decline of curiosity in enteroviruses, which ensued after the conquest of poliomyelitis, and the continual visual appeal within the limelight of recent, extra esoteric, and as a result extra "appealing" viruses.

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It is important to note that these chimeric viruses, which are completely PVl in the coding regions, replicated with nucleotide sequences in the 5' NTR derived from eVB3, some of them being tracts of peR dissimilarity mentioned above. ) spacer role as well as having some function. This function may be at the level of protein translation, RNA transcription, or perhaps in how the viral RNA and capsid proteins interact to promote packaging in the infected cell. What the function is, how the similar and dissimilar tracts relate to one another in terms of secondary and tertiary structure and function, and why different viral genotypes maintain partially unique sequences in this region are intriguing questions for further research.

1953, The coxsackie group of viruses, Ann. NY Acad. Sci. 56:587-595. 10. Sickles, G. , 1955, Recently classified types of coxsackie virus, group A. Behaviour in tissue culture, Proc. Soc. Exp. Bioi. Med. 90:529-531. 11. Sickles, G. , 1959, New types of coxsackie virus group A. Cytopathogenicity in tissue culture, Proc. Soc. Exp. Bioi. Med. 102:742-743. 12. Grist, N. , Bell, E. , 1978, Enteroviruses in human disease, Prog. Med. Virol. 24:114-157. 13. Gamble, D. , 1984, Enteroviruses: Polio-, ECHO-, and coxsackie viruses, in: Tapley and Wilson's Principles of Bacteriology, Virology and Immunity, Vol.

INTRODUCTION The purpose of this chapter is to summarize the development of our current understanding of the replication and molecular biology of coxsackieviruses (CV). To balance the discussion, the properties of the virion, its structural proteins, its genome, and some of its translational products are presented. As will become evident, most of the studies reviewed were conducted in group B coxsackieviruses (CVB) probably because CVB are easier to grow than group A coxsackieviruses (CVA) in tissueculture cells.

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Coxsackieviruses: A General Update by Brian W. J. Mahy (auth.), Mauro Bendinelli, Herman Friedman (eds.)


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