By Hari G. Garg, Charles A. Hales
It was once most likely the French chemist Portes, who first suggested in 1880 that the mucin within the vitreous physique, which he named hyalomucine, behaved in a different way from different mucoids in cornea and cartilage. 54 years later Karl Meyer remoted a brand new polysaccharide from the vitreous, which he named hyaluronic acid. at the present time its legit identify is hyaluronan, and modern day examine in this polysaccharide maintains to develop.
Expertly written by means of prime scientists within the box, this publication presents readers with a extensive, but particular evaluate of the chemistry of hyaluronan, and the position it performs in human biology and pathology. Twenty-seven chapters current a series major from the chemistry and biochemistry of hyaluronan, via its position in a number of pathological stipulations, to converted hylauronans as power healing brokers and at last to the practical, structural and organic houses of hyaluronidases. Chemistry and Biology of Hyaluronan covers the numerous fascinating points of this interesting molecule, and all chapters are meant to arrive the broader examine group. * finished examine the chemistry and biology of hyaluronans * sential to Chemists, Biochemists and clinical researchers * vast but exact overview of this swiftly starting to be study zone
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Additional resources for Chemistry and Biology of Hyaluronan
Anal Chem 1999; 71:1592 – 1596. 69. Kinoshita M, Okino A, Oda Y, Kakehi K. Anomalous migration of hyaluronic acid oligomers in capillary electrophoresis: correlation to susceptibility to hyaluronidase. Electrophoresis 2001; 22:3458 –3465. 70. Calabro A, Midura R, Wang A, West L, Plaas A, Hascall VC. Fluorophore-assisted carbohydrate electrophoresis (FACE) of glycosaminoglycans. Osteoarthritis Cartilage 2001; 9(Suppl A):S16 – S22. 71. Calabro A, Benavides M, Tammi M, Hascall VC, Midura RJ. Microanalysis of enzyme digests of hyaluronan and chondroitin/dermatan sulfate by fluorophore-assisted carbohydrate electrophoresis (FACE).
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Whistler RL, BeMiller JN. Alkaline degradation of polysaccharides. Adv Carbohydr Chem 1958; 13:289– 329. 56. Holmbeck S, Lerner L. Separation of hyaluronan oligosaccharides by the use of anion-exchange HPLC. Carbohydr Res 1993; 239:239– 244. 57. Midura RJ, Salustri A, Calabro A, Yanagishita M, Hascall VC. High-resolution separation of disaccharide and oligosaccharide alditols from chondroitin sulfate, dermatan sulfate and hyaluronan using CarboPac PA1 chromatography. Glycobiology 1994; 4:333 – 342.
Chemistry and Biology of Hyaluronan by Hari G. Garg, Charles A. Hales