By H.-J. Senn, U. Kapp
This quantity includes the most court cases of the fourth foreign convention on "Cancer Prevention 2006," which was once held in the course of February 16–18, 2006, in St. Gallen, Switzerland. Written by means of overseas specialists within the box, the e-book contains a complete replace at the most modern advancements within the upsurging fields of molecular biology and melanoma genetics and their interactions with scientific epidemiology and melanoma prevention at quite a few levels.
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In conclusion, GST genotypes may act differently, either by detoxifying harmful tobacco carcinogens and/or by eliminating lung cancer chemopreventive agents. The latter role for GSTT1 would explain the observed lower risk of SCC associated with GSTT1-null. The CYP3A isozymes play a pivotal role in the metabolism of numerous xenobiotics, including tobacco smoke constituents. The human CYP3A4 enzyme is involved in tobacco-specific nitrosamine- and BaP-metabolism, leading to genotoxic intermediates with subsequent DNAadduct formation.
Some of our current attempts to define such risk profiles are summarized below with special reference to polymorphic genes modulating tobacco smoke-induced lung cancer risk, chemotherapy response in lung cancer patients, and side effects in patients receiving radiotherapy. 2 Genetic Risk Profiles for Cancer Susceptibility and Therapy Response Genetic Risk Profiles for Cancer Susceptibility Genetic Variation in Metabolic Genes and Lung Cancer Risk We have carried out analyses of a hospital-based case–control study, investigating lung cancer risk, for a number of genetic polymorphisms in metabolic genes, such as those coding for phase I activating and phase II conjugating enzymes.
In our case–control study (389 Caucasian lung cancer patients, including 151 adeno- 2 Genetic Risk Profiles for Cancer Susceptibility and Therapy Response 23 N-Acetyltransferase genotypes Reference NAT1 slow and/or NAT2 fast NAT1 fast 1,22 Lung Cancer 1,92 Adenocarcinoma 1,02 SCC NAT2 slow 1,15 Lung Cancer 1,07 Adenocarcinoma 0,98 SCC Combined analysis NAT1 fast and NAT2 slow 2,22 Adenocarcinoma 0,1 1 10 Odds ratio Fig. 2 Lung cancer risk for NAT1 fast and/or NAT2 slow acetylators for different types of non-small cell lung cancer.
Cancer Prevention by H.-J. Senn, U. Kapp