By B. Singer, H. Fraenkel-Conrat (auth.), Roland F. Beers Jr., Werner Braun (eds.)
In contemporary years our horizons in regards to the position of nucleic acids in organic platforms were extended drastically by means of the discovering that those molecules not just hold and transmit particular infOImation but additionally can act as much less particular triggers of antiviral components and of immunological responses. The latter homes are of specific curiosity by way of attainable usage in human and veterinary drugs and therefore led, within the previous couple of years, to the advance of a brand new examine quarter that mixes either primary and utilized difficulties in a uniquely appealing means. additionally, the significance and the complexity of the issues has attracted investigators from many fields, together with molecular biologists, virologists, immunologists, chemists, biophysicists, oncologists, pharmacologists, and clinicians. A dialogue of latest advancements during this sector of organic results of polynucleotides, with specific emphasis on interferon induction and amendment of immune responses, consequently, appeared a logical subject for one of many annual symposia that Miles Laboratories, Inc. , has backed lately. The deal with ment of Miles permitted the recommendation with enthusiasm and hence once more earned the gratitude of the clinical neighborhood for sponsoring a catalytic assembly that used to be mostly all in favour of simple study difficulties and purely tangentially with instant functions. Springer-Verlag agreed to put up the court cases of the assembly which was once held on the Americana lodge in manhattan urban, June 4-5, 1970 and attracted an strangely huge audience.
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Extra resources for Biological Effects of Polynucleotides: Proceedings of the Symposium on Molecular Biology, Held in New York, June 4–5, 1970 Sponsored by Miles Laboratories, Inc.
Intranasal I excellent I Polynucleotide Virus Virus PVM PVM Columbia Columbia Columbia Columbia Route of administration I MU 9 coli- SK SK SK SK Columbia SK Vaccinia Vaccinia Vaccinia Parainfluenza 1 (Sendai) Parainfluenza 1 (Sendai) Rabies Rabies Rous sarcoma Influenza B Influenza A and A2 Yellow fever Marek's agent Marek's agent phage (replicative) poly I: C poly I: C poly I: C MU 9 coliphage (replicative) MU9 coliphage (replicative) poly I: C poly I: C M U 9 coliphage (replicative) poly I:C intranasal intranasal excellent , I I intranasal I intranasal very good intranasal intraperitoneal very good subcutaneous intraperitoneal very good intranasal intranasal I excellent intranasal intraperitoneal excellent intravenous intravenous intravenous intraperitoneal very good subcutaneous very good intraperitoneal very good intranasal intranasal good poly I:C intranasal intranasal good poly poly poly poly poly I:C I:C I:C I:C I:C intraplantar intracerebral intraperitoneal intranasal intranasal intraperitoneal intraperitoneal intraperitoneal intranasal intranasal weak weak weak weak none poly 1: C poly I:C poly I:C intracerebral intraperitoneal contact --~- 'I' intraperitoneal none intraperitoneal none intraperitoneal none 32 M.
Figure 2 shows the antibody responses in guinea pigs to 1 or 2 doses of bivalent influenza vaccine given as aqueous material with or without poly I: C or poly A: U and given in adjuvant 65 with or without added poly I: C or poly A: U. Poly I: C or poly A: U administered with aqueous vaccine caused comparatively weak potentiation of antibody response to these antigens. In certain instances, poly A: U was actually inhibitory. However, immunologic adjuvant 65 combined with poly I: C or poly A: U acted synergistically to cause a hyperpotentiation of antibody response which greatly exceeded the additive effects of adjuvant 65 and the complexed polynucleotides given singly.
BROOM: Dr. Singer or Dr. Fraenkel-Conrat, would it be fair to suggest that the mutagenic effects you observed with methylated poly Care due to the methyl C residues acting merely as a kind of spacer, as it were, an 21 22 Discussion indiscriminate one, and that the force necessary for the orientation of the nucleotide is just that factor? We think not, because many reactions, or all reactions we study cause loss of activity in terms of incorporation of GTP and that, we think, is an expression of the absence of functional nucleotides.
Biological Effects of Polynucleotides: Proceedings of the Symposium on Molecular Biology, Held in New York, June 4–5, 1970 Sponsored by Miles Laboratories, Inc. by B. Singer, H. Fraenkel-Conrat (auth.), Roland F. Beers Jr., Werner Braun (eds.)