By S. M. Fischer, T. J. Slaga (auth.), Susan M. Fischer, Thomas J. Slaga (eds.)
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462-494, 1978. C. B. Superoxide dismutase activity in leukocytes. J. Chm. Invest. 53: 1197-1201, 1974. J. Diminuition of mouse superoxide dismutase and catalase activities by tumor promoters. :1141-1146, 1981. Chapter 3 PROSTAGLANDINS, EPIDERMAL HYPERPLASIA AND SKIN TUMOR PROMOTION Gerhard Furstenberger and Friedrich Marks German Cancer Research Institute Heidelberg, Germany Page I. II. III. IV. V. Introduction . . • • . The role of prostaglandins in epidermal cell proliferation in vivo ••• A.
Effect of Inhibitors of Arachidonate Metabolism on TPA-induced Chemiluminescence in Mouse Epidermal Cells. 1 1 111 10 106 84 100 Fl urbi profen 9 99 1 110 10 93 100 79 7 a10 murine epidermal cells were used per 3 ml assay; the cpm at the peak of the response was used to determine percent of the TPA response. Experiments were done twice, on different cell isolations. b5,8,ll,14 eicosatetraynoic acid cnordihydrogauiaretic acid dpreincubation used 42 v. CONCLUSION The above studies indicate that while the prostaglandins or other metabolites of arachidonic acid metabolism that have been tested to date are not tumor promoters themselves, they play an integral part in the underlying mechanism of tumor promotion.
5 o , 10' j I 10' 10' A 10' B 1~3 C i , 1~4 102 0" I i 1'03 D , 10' of the control FIGURE 2. 1 ml acetone. The mice were killed at the times indicated. For determination of epidermal prostaglandin E content, ODe activity, DNA labeling and mitotic activity, see 11,14. Each value is the mean of at least 6 mice. Notwithstanding the fact that prostaglandins do not stimulate epidermal cell proliferation in untreated skin, PGE2 shows a comitogenic effect when applied simultaneously with TPA (19). A similar comitogenic effect has been found to be exerted by PGF2a although this prostaglandin is unable to overcome indomethacin inhibition of TPA-induced hyperplasia.
Arachidonic Acid Metabolism and Tumor Promotion by S. M. Fischer, T. J. Slaga (auth.), Susan M. Fischer, Thomas J. Slaga (eds.)