By W. J. Spillane (auth.), T. H. Grenby (eds.)
The topic of sweeteners maintains to enhance and extend, however the development that's being made is probably not obvious for all to work out, because of adjustments which have been occurring in how study is funded and the destinations the place it's now mostly performed. In former instances clinical development used to be rated as a prized a part of the output of educational examine laboratories and associations. this day, despite the fact that, it's more and more most probably that significant advances emanate mainly from the learn and improvement devices of commercial and advertisement firms and corporations. this implies after all that the paintings turns into extra interested by attaining particular advertising pursuits, yet as a result of the excessive point of dedication, price and committed enter required, e-book of the findings has a tendency to take a decrease precedence, and should really be barred if there's any probability of lack of the economic facet or virtue which has been one of many ambitions of the study. therefore one of many items of getting ready this ebook has been to gather jointly details that may in a different way stay unpublished on advances within the box of sweeteners. Of the fifteen contributions which shape the chapters, merely thirteen% originate from educational departments, while in prior books of studies on comparable subject matters, contributions from educational resources accounted for up to 50% (Developments in Sweeteners, vols 2 and three, 1987 and 1989) and sixty four% (Progress in Sweeteners, 1989).
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Pp. 14-27. Kodama, S. (1920) Taste. 1. Chern. Soc. (Japan) 41, 495-534. Oertly, E. G. (1919) Simple relations between the constitution of aliphatic compounds and their sweet taste. J. Amer. Chern. Soc. 41, 855-867. S. E. (1967) Molecular theory of sweet taste. Nature 216, 480-482. S. G. (1977) A lipophilic-hydrophobic attribute and component in the stereochemistry of sweetness. Food Chern. 2, 145-153. -M. and Nofre, C. (1991) Design of sweeteners. E. T. E. DuBois), ACS Symp. Series 450, American Chemical Society, Washington DC.
The FDA knows that any sweetener worth its salt will need to be in fairly broad use to be commercially viable. This was the approach taken in the 1986 and 1987 petitions for alitame and sucralose, which, as of March 1995, are still making their way through the exacting FDA review process. As for the question of concurrent submissions in other countries, again there are conflicting considerations. There are very few deep-pocketed companies that would opt to submit petitions only in the USA and await FDA approval before submitting elsewhere.
As well as being under consideration by the SCF, the new sweeteners sucralose and alitame are currently going through this United Kingdom approval process. The F AC has agreed a case of need for both sweeteners, and the safety assessments are in train. In cases such as these there is nothing to prevent a company simultaneously requesting approval from both the EU and a single member state. It is for the company concerned to decide which route is preferable. One advantage of the 'national' route is that a definite timetable for European action is laid down once national authorisation has been achieved.
Advances in sweeteners by W. J. Spillane (auth.), T. H. Grenby (eds.)